Be part of us to discover tailless mRNA detection with the BioPhase 8800 system and the RNA 9000 Purity & Integrity equipment. Improve mRNA therapeutics with superior strategies.
Register Free: https://www.chromatographyonline.com/lcgc_w/tailless-mrna
Occasion Overview:
As mRNA-based therapeutics proceed to advance, there may be an growing want for high-resolution analytical strategies able to distinguishing RNA strands of comparable size. One essential high quality attribute (CQA), highlighted within the USP draft chapter on analytical procedures for mRNA vaccines, is the evaluation of the share of transcripts missing a 3’ poly(A) tail. The draft chapter recommends ribonuclease H-mediated focused cleavage adopted by ion-pair reverse-phase HPLC (IP-RP-HPLC) as an acceptable know-how to evaluate this CQA. Another strategy is capillary gel electrophoresis (CGE), which is properly established as an analytical know-how within the mRNA subject to evaluate mRNA fragmentation and integrity.
Be part of us for a webinar as we talk about methods to resolve tailless mRNA from full size transcripts utilizing the BioPhase 8800 system and the RNA 9000 Purity & Integrity equipment. Study how one can assess mRNA integrity and quantify mRNA impurities to a excessive diploma of accuracy utilizing the facility of multicapillary electrophoresis.
Key Studying Aims:
- Perceive the analytical challenges in detecting tailless mRNA species
- Discover methods to use multicapillary electrophoresis to resolve similar-length mRNA species
- Discover ways to detect mRNA impurities utilizing GCE and its decision capabilities
Who Ought to Attend:
- Administrators of R&D
- Senior analysis scientists
- Chief technical officers
- Principal scientist
- Expertise administrators
Speaker:
Ryan Williams
Senior Scientist – Analytics
Vernal Biosciences
Ryan Williams is a senior analytical scientist at Vernal Biosciences. With over a decade of biomolecule expertise in ISO-compliant environments, he excels in purification and bioanalytical technique growth. He focuses on mRNA analytics and detecting difficult impurities. Williams holds a BS in biology from Norwich College.
Register Free: https://www.chromatographyonline.com/lcgc_w/tailless-mrna
