Analysis targets lysosomal operate restoration for neurodegeneration
Endlyz Therapeutics has launched from stealth, unveiling its pipeline of small molecule modulators designed to revive lysosomal operate in Parkinson’s illness (PD) and different neurodegenerative circumstances.
The corporate additionally introduced a $2.2 million grant from the Michael J. Fox Basis for Parkinson’s Analysis and a collaboration with Prof. Peter Vangheluwe at KU Leuven.
Endlyz focuses on ATP13A2 and ATP10B, polyamine and lipid transporter enzymes crucial for neuronal well being. Its lead small molecule potentiators of ATP13A2, linked to the PARK9 gene, intention to fight endo-lysosomal dysfunction, a key driver of neurodegeneration.
Dr. Joanna Wolak, CEO and co-founder of Endlyz, mentioned: “Our small-molecule ATP13A2-targeting sequence represents a ground-breaking strategy to treating Parkinson’s illness. By restoring lysosomal operate, we intention to sluggish or halt illness development reasonably than merely tackle signs.”
The collaboration with Prof. Vangheluwe, a world knowledgeable in lysosomal transporters, will leverage his analysis and CD3 at KU Leuven’s drug discovery experience. Supported by Quantum AI, the partnership goals to speed up candidate drug discovery for activating ATP10B.
Endlyz is supported by main buyers, together with SV Well being Buyers’ Dementia Discovery Fund, Oxford Science Enterprises, AbbVie Ventures, and Parkinson’s UK. The corporate plans to safe further funding in 2025 to advance its lead programme via IND-enabling research, develop its pipeline, and discover new indications.
The Michael J. Fox Basis funding will allow biomarker discovery to bridge preclinical and scientific growth, enhancing translational analysis and therapeutic innovation for neurodegeneration.
Analysis targets lysosomal operate restoration for neurodegeneration
Endlyz Therapeutics has launched from stealth, unveiling its pipeline of small molecule modulators designed to revive lysosomal operate in Parkinson’s illness (PD) and different neurodegenerative circumstances.
The corporate additionally introduced a $2.2 million grant from the Michael J. Fox Basis for Parkinson’s Analysis and a collaboration with Prof. Peter Vangheluwe at KU Leuven.
Endlyz focuses on ATP13A2 and ATP10B, polyamine and lipid transporter enzymes crucial for neuronal well being. Its lead small molecule potentiators of ATP13A2, linked to the PARK9 gene, intention to fight endo-lysosomal dysfunction, a key driver of neurodegeneration.
Dr. Joanna Wolak, CEO and co-founder of Endlyz, mentioned: “Our small-molecule ATP13A2-targeting sequence represents a ground-breaking strategy to treating Parkinson’s illness. By restoring lysosomal operate, we intention to sluggish or halt illness development reasonably than merely tackle signs.”
The collaboration with Prof. Vangheluwe, a world knowledgeable in lysosomal transporters, will leverage his analysis and CD3 at KU Leuven’s drug discovery experience. Supported by Quantum AI, the partnership goals to speed up candidate drug discovery for activating ATP10B.
Endlyz is supported by main buyers, together with SV Well being Buyers’ Dementia Discovery Fund, Oxford Science Enterprises, AbbVie Ventures, and Parkinson’s UK. The corporate plans to safe further funding in 2025 to advance its lead programme via IND-enabling research, develop its pipeline, and discover new indications.
The Michael J. Fox Basis funding will allow biomarker discovery to bridge preclinical and scientific growth, enhancing translational analysis and therapeutic innovation for neurodegeneration.
